Sherlock Holmes and his unconditional partner Dr. Watson will have to use their intellectual sharpness and all kinds of resources and abilities to defeat a new enemy: Lord Henry Blackwood. He is sentenced to death for the practice of black magic and the attempted murder of a young woman: Irene Adler, who happens to be Watson’s girlfriend. However, after the gallows Blackwood is missing from his cofﬁn. In his place there is Holmes’ housekeeper: Mrs. Hudson. Now, Sherlock Holmes and Dr. John Watson will rush to disrupt an evil conspiracy that tends to claim more victims and that may change the very origins of nature.